Proteinuria with and without Renal Glomerular Podocyte Effacement
نویسندگان
چکیده
منابع مشابه
Proteinuria with and without renal glomerular podocyte effacement.
Renal biopsies of patients with proteinuria and kidney disease most often are associated with podocyte foot process effacement. For several decades, nephrologists have wondered whether proteinuria is a result of podocyte foot process effacement or the cause of it. In the past few years, the author's laboratory has addressed this issue using different mouse models of proteinuria. Although in mos...
متن کاملCorrelation between Podocyte Foot Process Effacement and Proteinuria in Human Glomerular Diseases
The podocyte is a specialized epithelial cell with numerous interdigitating foot processes which play an important role in the regulation of the glomerular basement membrane (GBM) permeability. The nephrotic syndrome results from increased glomerular permeability to proteins and is structurally belived to be associated with podocyte foot process effacement. Despite increasing knowledge of the m...
متن کاملInhibition of podocyte FAK protects against proteinuria and foot process effacement.
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that plays a critical role in cell motility. Movement and retraction of podocyte foot processes, which accompany podocyte injury, suggest focal adhesion disassembly. To understand better the mechanisms by which podocyte foot process effacement leads to proteinuria and kidney failure, we studied the function of FAK in podocytes. In mur...
متن کاملPodocyte-specific expression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endothelia.
Angiopoietin-2 (Ang-2) modulates embryonic vascular differentiation primarily by inhibiting the antiapoptotic effects of Ang-1 on endothelia that express the Tie-2 receptor. Ang-2 is transiently expressed by developing glomeruli but is downregulated with normal maturation. Glomerular Ang-2 expression is, however, markedly upregulated in animal models of diabetic nephropathy and glomerulonephrit...
متن کاملPodocyte Damage and Glomerular Permeability
The renal glomerulus, the site of plasma ultrafiltration and the production of primary urine (1), is the locus of a number of progressive disorders that lead to chronic renal insufficiency. Before the advent of renal replacement therapies, these diseases invariably led to death by uremia. Still, while these treatments save, or at least extend, patient’s lives, they do so at an enormous price, b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2006
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2006060628